In model 2, for adiponectin levels, significant negative associations were noted with overweight (P = 0.002), obesity (P = 0.001) and HOMA-IR (P = 0.010) and the model accounted for 26 % (r2 = 0.26) of the variability in adiponectin levels. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.