i) the children were healthy, comparable between groups for age, sex and Tanner stage distributions and presented no associated diseases that could influence the metabolic profile, ii) the use of traditional markers for metabolic disease (ie, lipid profile, insulin levels, HOMA-IR) and the measurement for the first time of adiponectin, leptin and ghrelin concentrations in a sample of Guadeloupean children and iii) the providing of data on changes in metabolic parameters at the end of the lifestyle intervention. The gene discussed is LEP; the disease is metabolic disease.