Consistent induction of protein expression levels of p-eIF2α and CHOP was observed both at 17 wks (Fig. 4H,I) (AD v.s. CR, cohort 2) and 22 wks (Fig. 6H,I) (AD-Veh v.s. CR-Veh, cohort 3), supporting an involvement of ER stress augmentation in the continuous deterioration of hepatic steatosis after undernourishment in utero. This evidence concerns the gene EIF2A and fatty liver disease.