INS and Alzheimer disease: The TUDCA treatment significantly decreased the plasma levels of total cholesterol, LDL cholesterol, HDL cholesterol, and small dense LDL cholesterol in CR pups (CR-Veh v.s. CR-TU), but not in AD pups (Table 1A), but did not cause significant changes in the serum levels of chylomicron cholesterol, VLDL cholesterol, total triglycerides, glucose, or insulin (Table 1A).