Serglycin is also implicated in the biosynthesis and secretion of growth factors and inflammatory mediators such as HGF and CXCL1 in plasma [5] and endothelial cells [31, 32], respectively, as well as in the production of proteases in several inflammatory cells, which have proven roles in cancer cell growth and spread [3, 23]. This evidence concerns the gene CXCL1 and cancer.