The disruption of the FS-localized glycolytic enzymes consequently exhibit defects in sperm motility that therefore have sluggish movement resulting in male infertility (Danshina et al., 2010; Miki et al., 2004; Nakamura et al., 2013; Narisawa et al., 2002; Odet et al., 2013). This evidence concerns the gene HK1 and male infertility.