However, when analyzing IgG and claudin-5 signals, reflecting vessel extravasation and tight junction function, respectively, in the infarct core and/or peri-infract region, we did not find evidence for alterations in post-stroke BBB integrity induced by knocking out the gene encoding IFN-β, at least not 2 days after tMCAo. The gene discussed is IFNB1; the disease is Stroke.