Nevertheless, Fra-2 appears to play a critical role in tongue tumorigenesis since selective silencing of Fra-2 led to downregulation of tumorigenic genes; c-Fos, c-Jun, MMP-9 and HPV E6/E7 but upregulation of p53 and Fra-1 that may chemo-radio-sensitize tongue cancer cells leading to better treatment outcome. The gene discussed is JUN; the disease is tongue cancer.