Disease causing variants have been detected in IL-10, IL-10R [1–4], CYBB, CYBA, NCF1, NCF2 and NCF4 (chronic granulomatous disease), FOXP3, WAS, MEFV, ITGB2, as well as other genes in patients with severe VEO-IBD [3, 5–7]. Here, IL10RA is linked to inflammatory bowel disease.