Although genetic activation of AKT (24 h or 48 h prior to ischemia) protected the heart from ischemic insults [42, 43], more acute activation of AKT by SC79 and chronic AKT activation in ob/ob mice prior to ischemia did not confer protection against ischemia/reperfusion injury [44, 45]. The gene discussed is AKT1; the disease is ischemia.