The origin of these findings is based on the distinct nature of the cell lines utilized in our studies; LNCaP cells are originated from a lymph node metastasis [25] and VCaP cells are generated from a vertebral metastatic lesion and harbor the TMPRSS2-ERG fusion (present in 40–60 % of PCa patients) [26, 27]. Here, ERG is linked to posterior cortical atrophy.