We also observed that circulating alpha-1-acid glycoprotein (A1AG1), leucine rich globulin (LRG1), fibrinogen (FIB) -A and -B chains, and alpha antitrypsin (AATC)/ SERPINA1 proteins were elevated in IPA vs matched controls (Fig 3A). This evidence concerns the gene LRG1 and Ito hypomelanosis.