However, it has been reported that MitoQ (mitochondrial ROS scavenger) was able to attenuate body weight gain and glucose intolerance provoked by high fat diet, while Apocynin (NADPH oxidase inhibitor) and Allopurinol (xanthine oxidase inhibitor) showed limited effects, thus suggesting secondary roles of xanthine oxidase or NADPH oxidase-dependent ROS production in the onset of oxidative stress-dependent obesity, glucose intolerance, and hepatic steatosis process [48]. Here, XDH is linked to obesity due to melanocortin 4 receptor deficiency.