Hence excess TG in the liver results in hepatic steatosis, fibrosis and non-alcoholic steatohepatitis (NASH) [3,4]; fat in the pancreas is associated with impaired insulin secretion, β-cell dysfunction and apoptosis [5,6]; excess intramyocardial fat leads to cardiomyopathy, coronary heart disease and sudden death [7,8]; in the skeletal muscles, intramyocellular TGs are associated with insulin resistance and impaired glucose uptake [1,9]. This evidence concerns the gene INS and metabolic dysfunction-associated steatohepatitis.