Higher intake of dietary magnesium, which is a component of nuts and many whole foods, especially animal products, but also recorded in highly studied grains, is also associated with reduced risk of IR [174,175] and T2DM [176], whereas magnesium supplementation improves measure of glucose and insulin metabolism in subjects with IR [177] and T2DM [178] as well as in generally healthy adults [179]. Here, INS is linked to type 2 diabetes mellitus.