BIRC5 and breast cancer: Trabectedin, on the other hand, was suggested to induce apoptosis in resistant breast cancer cell lines either through the up-regulation of DR4, DR5, and FADD and the down-regulation of XIAP and survivin or through the up-regulation of Bax and Bak and the down-regulation of Bcl-2, Bcl-xL and survivin, in MCF7 and MDA-MB-453, respectively [181].