Activation of NF-κB canonical pathway has mostly been demonstrated to inhibit TRAIL-induced apoptosis through up-regulation of c-FLIP [96,98,119,155,156,157,158,159,160,161,162,163,164,165], but a recent study demonstrated that its activation in glioblastoma cells could contribute to Fas/CD95- and TRAIL-induced apoptosis [166]. The gene discussed is FAS; the disease is glioblastoma.