However, the ability of caspase-10 to substitute for a lack of caspase-8 remains a matter of debate [15], despite the fact that this initiator caspase was shown to restore both TRAIL- and Fas ligand-induced apoptosis in caspase-8-deficient neuroblastoma [16] and the caspase-8-deficient Jurkat T lymphoma derivative cell line [17]. This evidence concerns the gene CASP8 and neuroblastoma.