Similar to ERK, activation of JNK or p38, depending on the tumor cell line and trigger, can act in a transcriptional-dependent or independent manner to induce the regulation of TRAIL agonist receptors, c-FLIP or Bcl-2 family proteins to restore or inhibit apoptosis-induced by TRAIL [91,109,121,122,123,124,125,126,127,128,129,130,131,132,133]. This evidence concerns the gene TNFSF10 and neoplasm.