It interacts with EZH2, SUZ12, and the PRC1 subunit CBX7 (ADP Ribosylation Factors) mediating the silencing of p16INK4a, p15INK4b and p14ARF tumor suppressors through the recruitment of PRC2 and PRC1 [132,133,134]. The gene discussed is EZH2; the disease is neoplasm.