In a study by Achary, radioresistant cervical cancer cell lines were shown to overexpress the CYP1B1 gene, hinting a potential role in resistance to radiation therapy, whereas patients with various advanced-stage malignancies, vaccinated with ZYC300, a plasmid encoding an inactivated form of CYP1B1 DNA, also responded significantly better to salvation chemotherapy [35,36]. Here, CYP1B1 is linked to cervical carcinoma.