RUNX1 and acute lymphoblastic leukemia: Seventeen miRNAs were significantly downregulated in ETV6/RUNX1-positive ALL samples (Table 1), and of these, miR-181a-1, which is derived from the 3′ arm of precursor hsa-mir-181a-1 (Fig 1A), had the most significant P-value and showed a remarkable 4-fold decrease (Table 1).