This induction partially altered the lymphocytic differentiation as shown by the CD10 hyperexpression decrease in cells from two of three ETV6/RUNX1-positive samples (Fig 5D and S2 Fig), suggesting that the level of miR-181a expression is important for the perturbation of the lymphocytic differentiation program in ETV6/RUNX1 ALL. Here, RUNX1 is linked to acute lymphoblastic leukemia.