The finding that both miR-181a-1 and miR-181c/d are significantly downregulated in ETV6/RUNX1 ALL (Table 1) and that all members of the miR-181 family share the same seed sequence within their 5′ arms and in targets led us to investigate which downstream genes are regulated by miR-181a. The gene discussed is ETV6; the disease is acute lymphoblastic leukemia.