This is further supported by a lack of apparent genotoxicity in ONC201-treated cells [10], ONC201 also displays a lack of resistance that is likely a consequence of sharp dose-response curves in tumor cells that confounds the evolution of drug resistance and efficacy in the face of common mechanisms of resistance such as PgP overexpression, cancer stem cells, and genetic aberrations [14, 17]. Here, PGP is linked to cancer.