Recently, we showed that the flux of sugars through the pentose phosphate pathway (PPP), in association with the upregulation of some glucose metabolism-related enzymes including GPI, promoted both cancer cell proliferation and migration, as well as anabolic reactions in ccRCC.9 In the present study, we assessed the role of GPI/AMF as a prognostic factor for ccRCC cancer-specific (CSS) and progression-free survival (PFS). Here, GPI is linked to nonpapillary renal cell carcinoma.