Many studies have shown that GPI/AMF and AMFR are overexpressed in some tumors, have a role in cancer progression and are negatively associated with patients’ clinical outcome.9,38–40 In a recent study, we explored the role of glycolysis and PPP in ccRCC and evaluated the activation of the GPI–AMFR axis in this tumor.9 In particular, we found that GPI was overexpressed in ccRCC, in association with high levels of glucose 6-phosphate and fructose 6-phosphate. Here, AMFR is linked to nonpapillary renal cell carcinoma.