The observed efficacy is consistent with results from 2 studies in which this combination provided rapid control of severe hypercortisolism elicited by ACTH-dependent Cushing's syndrome6 (a combination of mitotane, metyrapone, and ketoconazole in this study) and by ectopic ACTH syndrome or adrenal carcinoma.7 Here, POMC is linked to ACTH Syndrome, Ectopic.