Cushing's syndrome was due to unilateral adrenal adenoma in 5 cases,11,12,14,15,17 ACTH-secreting adenoma in 4 cases,9,10,13,18 and of unknown cause in 1 case.16 LVEF improvement was noted whatever the initial etiology, with a median improvement of 30% (min: 15%; max: 42%) for adrenal adenomas, 25% (min: 15%; max: 33%) for pituitary adenomas, and 38% after bilateral adrenectomy in the subject for whom the cause was undetermined. The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.