Apart from that, the G allele of rs6983267 has been conferred to increase the risk of CRC by interacting with the promoter of MYC oncogenes,48–50 which was an aberrant expression in numerous tumors, including gastric cancer.51 Moreover, a relationship between SNP of rs7014346 and CRC susceptibility was discovered in a GWAS44 and previous study has also suggested that the GA genotype of rs7014346 was significantly associated with a decreased risk of breast cancer. This evidence concerns the gene MYC and colorectal carcinoma.