The rs10505477 SNPs, also located in the chr.8q24 region, were significantly associated with the risk of CRC43,45,52 and breast cancer.53,54 Ma et al10 hypothesized that rs10505477 in LncRNA CASC8 was involved in gastric cancer progression and it might serve as a potential prognosis marker in the Chinese population. The gene discussed is CASC8; the disease is breast cancer.