It has been proved to promote the antiinflammatory effects of TGF-β signaling via binding to TAB2 and TAB3 and inhibiting TAK1.16,17 Apart from that, TGF-β plays an important role in promoting metastasis in many solid tumors.18 Studies have indicated that SMAD7 gene is related with breast cancer,19 gastric cancer,20 pancreatic cancer,21 CRC,22 and so on. The gene discussed is SMAD7; the disease is colorectal carcinoma.