The cell cycle inhibitor protein hampers enzymatic activation of cyclin E/CDK2 complexes and induces cell cycle arrest at G1 phase.5 Lower expression of cyclin-dependent kinase inhibitor CDKN1B related to tumorigenesis and advanced clinical stage has been identified in multiple types of cancer, such as cancers of prostate, gastric, laryngeal, colorectal, and breast.6–10. This evidence concerns the gene CCNE1 and cancer.