CEACAM-1 [68, 69], CEACAM-6 [70–72], CD133 [73–75], S100A4 [76–80], and midkine [81] have been shown to be biomarkers that are also expressed in PC and are significantly associated with invasion and metastasis in PC and PC prognosis. This evidence concerns the gene CEACAM6 and pachyonychia congenita.