The tumor microenvironment consists of a variety of cell types including fibroblasts, immune cells, and endothelial cells, as well as non-cellular components such as the extracellular matrix (ECM), ECM remodeling enzymes [e.g., matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), and lysyl oxidases (LOXs)], and growth factors (e.g., VEGF, TGF-β, and PDGF). The gene discussed is LOX; the disease is neoplasm.