CDH1 and renal cell carcinoma: In contrast, IL-15 production is not altered in RCC but the IL-15 signaling pathway is profoundly modified because of the expression of a particular transmembrane IL-15 form and the defective expression of CD132 (γc chain of the IL-2 receptor family) and JAK3 (41), which both favor EMT through down-regulation of E-cadherin expression (42).