PTGS2 and nonpapillary renal cell carcinoma: Proangiogenic effect of overexpressed CK2 could additionally be mediated by local overproduction, by tumoral and peripheral blood mononuclear cells, of prostaglandin E2 (PGE2), the most predominant and biologically active eicosanoid produced by cyclooxygenase 2 (COX-2); this enzyme is indeed often upregulated in ccRCC, likely through a CK2-induced Wnt/β-catenin pathway and its expression is correlated with prognosis [see for review in Ref.