PRKDC and lung carcinoma: For example, cells with defective DNA-PKcs activity show increased radiosensitivity, and in lung carcinoma cell lines after γ-irradiation, the lowest DNA-PKcs protein content and kinase activity was found in the most radiosensitive cells, U-1285 and H-69, while the highest was found in the most radioresistant cells U-1810 (57, 58).