M1, the classically activated MΦ/Mo induced by IFN-γ and bacterial products, display high antigen presentation efficiency due to upregulation of MHCII (HLA-DR) and co-stimulatory molecules (CD80 and CD86), express high levels of IL-12 and low IL-10, and thus activate Tc1/Th1 anti-tumor responses. Here, CD86 is linked to neoplasm.