FCGR2A and cancer: Since FcγR are widely expressed on myeloid cells, and the Fc portion of cetuximab, human IgG1 (hIgG1), can bind to FcγR such as FcγRIII (CD16) and trigger the downstream signaling, we hypothesized that cetuximab may directly act on the FcγR on the myeloid cells to ameliorate their suppressive phenotypes in cancer patients.