Translocation of calreticulin to the outer membrane of dying cells was originally described to occur during immunologic cell death [44, 45]; however, translocation of this molecule to the cell surface has also been described to occur in non-dying cells that are undergoing immunogenic modulation [36], where exposure of tumor cells to certain chemotherapies and radiation, induces phenotypic changes in viable cells that makes them more susceptible to immune mediated killing. Here, CALR is linked to neoplasm.