TEK and neoplasm: To determine whether inhibition of the angiopoietin/Tie2 axis has a direct proliferative or cytotoxic effect on human tumor cells, OV17-1, MDA-MB-231, and LNCaP tumor cells were treated in vitro for 3 days with the Cmax of mL4-3 and L1-7(N) (16 and 10 μg/mL, respectively).