ICAM1 and neoplasm: Pretreating tumor-cell targets with mL4-3 and L1-7(N) significantly increased lysis of OV17-1 cultures by CEA-specific T cells (from 29 to 74 %), while the addition of an anti-ICAM-1 blocking antibody, but not the corresponding isotype control, significantly reduced lysis (from 74 to 40 %) (Fig. 5).