Moreover, although ABCA1 has not been found to be associated with this trait in GWAS or candidate gene association studies, a dietary intervention study including nopal, chia seed, soy protein and oat reported that individuals with metabolic syndrome bearing the ABCA1/R230C variant responded with a greater decrease in body weight and a sharper increase in serum adiponectin concentrations [40]. The gene discussed is ADIPOQ; the disease is metabolic syndrome.