Although the ABCA1/R230C diet interactions affecting HOMA-IR observed here had marginal significance (Pinteraction = 0.058 and 0.075 for dietary fat and carbohydrate intake respectively), our data suggest that gender and diet are factors that added to ABCA1 function participate in the complex process of insulin resistance, and deserve further study. The gene discussed is ABCA1; the disease is Insulin resistance.