Higher levels of both soluble factors were detected in HNSCC patients compared to HCs (sMICA, median: 532.8 versus 5.9 pg/ml; TGF-β1, median: 48.9 × 104 versus 10.9 × 104 pg/ml, respectively) (Figure 1B). The gene discussed is TGFB1; the disease is head and neck squamous cell carcinoma.