TAAR1 agonists also suppress hyperactivity and improve cognition in glutamate receptor deficiency models (Revel et al., 2011, 2013) and TAAR1 modulates cortical glutamate NMDA receptor function in TAAR1 KO mice (Espinoza et al., 2015). This evidence concerns the gene TAAR1 and hyperinsulinemic hypoglycemia, familial, 4.