Dysregulation of the IL-1β system in the brain has been implicated in AD, MS and epilepsy (Garlind et al., 1999; Ravizza et al., 2006; Dujmovic et al., 2009) Cytokine receptors for IFNs and a few ILs are coupled to the JAK/STAT pathway. Here, IL1B is linked to myeloid sarcoma.