CFH and age-related macular degeneration: To add another layer of genetic complexity for post-transcriptional regulation, both miRNA-146a and miRNA-155 recognize an overlapping 3′ untranslated region (3′UTR) of the complement factor H (CFH) mRNA (highlighted in green; CFH loss-of-function mutations or CFH expression deficits are associated with both AD and AMD; see below; Figure 1D).