DLX3 and tricho-dento-osseous syndrome: Thus, taurodontism is a key feature of tricho-dento-osseous syndrome (TDO; 1OMIM#190320) which besides is characterized by kinky, curly hair during childhood and adolescence, hypoplastic-hypomaturation type amelogenesis imperfecta, and increased bone density due to dominant mutations of the homeobox gene DLX3 (Figures 3B–F; Wright et al., 1997, 2008; Price et al., 1998).