ADIPOQ and diabetes mellitus: Okada-Iwabu and collaborators observed that orally active AdipoR agonists (AdipoRON) presented similar effects to adiponectin via AdipoR1 and 2 in both liver and skeletal muscle of diabetic mouse model, suggesting that adiponectin receptors could be a promising therapeutic target for the oral treatment of DM (Okada-Iwabu et al., 2013).