Recent studies including our previous study demonstrated that the upregulation of ion channels (Orai/STIM, TRPV1, TRPA1, and KCa3.1) in CD4+ T cells was involved in the pathogenesis of IBD, while their pharmacological blockade elicited a significant decrease in IBD disease severity (Di Sabatino et al., 2009; Di et al., 2010; Bertin et al., 2014; Kun et al., 2014; Ohya et al., 2014). Here, KCNN4 is linked to inflammatory bowel disease.