In addition, transgenic mice overexpressing HO-1 is also protective against diabetic cardiomyopathy in mice, and this set of circumstances is associated with restored expression of Amp-associated kinase (AMPK) and AKT/PKB activation compared with mice with HO-1 deletion (Zhao et al., 2013). The gene discussed is HMOX1; the disease is diabetic cardiomyopathy.