THBS1 and neoplasm: Indeed, its ability to interact with multiple ligands enables TSP-1 to regulate a wide range of processes such as tumor cell adhesion (Li et al., 2006), proliferation (Sick et al., 2011), survival or apoptosis (Manna and Frazier, 2004; Saumet et al., 2005; Rath et al., 2006a,b), tumor invasion and metastatic dissemination (Jayachandran et al., 2014; Borsotti et al., 2015), inflammation, immune response (Grimbert et al., 2006) and response to treatment (Lih et al., 2006; Bi et al., 2014).