It should be noted that similar inhibition of tumor growth is observed when irradiating TSP-1 null mice, thus suggesting that anticancer targeting of TSP-1:CD47 interaction would be of a greater relevance than disrupting CD47:SIRPα (Isenberg et al., 2008c; Soto-Pantoja et al., 2013b). The gene discussed is CD47; the disease is neoplasm.