Indeed, TSP-1/CD36/CD47 trimolecular signaling platform dynamics as well as interactions involving co-receptors and soluble ligands exert pleiotropic activities on cancer progression, by directly modulating cancer cells behavior or by acting on tumor microenvironment stromal cells (Kazerounian et al., 2008; Sick et al., 2012). The gene discussed is CD47; the disease is neoplasm.