In recent years, an increasing number of studies have tended to present TSP-1 as a poor prognosis and recurrence marker in many cancer types including glioma (Perez-Janices et al., 2015), melanoma (Borsotti et al., 2015) as well as ovarian and pancreatic carcinomas (Lyu et al., 2013; Nie et al., 2014; Pinessi et al., 2015). This evidence concerns the gene THBS1 and melanoma.