Data concerning serum AGEs and RAGE levels in MCI subjects with diabetes are lacking; therefore, the aim of the study was to (1) evaluate serum levels of AGEs, RAGE, and CRP in elderly patients with T2DM with and without MCI and (2) determine the predictors (including AGEs, RAGE, and CRP levels) of having MCI in elderly patients with T2DM. Here, CRP is linked to type 2 diabetes mellitus.