The univariate logistic regression models revealed that variables which increased the likelihood of having been diagnosed with MCI in elderly patients with type 2 diabetes were higher levels of HbA1c, RAGE, AGEs, CRP, TG, lower level of HDL cholesterol, previous CVD, HA or use of HA drugs, hyperlipidemia, retinopathy, nephropathy, increased number of co-morbidities, older age, and less years of formal education (Table 4). The gene discussed is AGER; the disease is retinal disorder.