In particular, the PrPC-dependent activation of Fyn was identified as central to couple PrPC-Aβ complexes to NMDA-R redistribution, Ca2+ signaling alterations, tau hyper-phosphorylation, spine loss and death in neurons, and AD pathology in mice (Larson et al., 2012; Um et al., 2012). Here, PRNP is linked to Alzheimer disease.