NF-κB is one of the major regulators of neuroinflammatory activation of glia (Zamanian et al., 2012) and its induction is seen in post-mortem ALS tissue, mutant SOD-1 and TDP-43 models (Migheli et al., 1997; Swarup et al., 2011a,b; Frakes et al., 2014). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.