Up-regulation of GSK-3 activity leads to phosphorylation of the amyloid precursor protein (APP) and the protein tau, both of which are associated with the pathological processes that lead to the hallmarks of Alzheimer's disease (AD), amyloid-β plaques and neurofibrillary tangles (Hanger and Noble, 2011; Avila et al., 2012). This evidence concerns the gene APP and Alzheimer disease.