SOD1 and amyotrophic lateral sclerosis: Since then, other studies have confirmed Golgi fragmentation in 10–50% sporadic patients (Gonatas et al., 2006; van Dis et al., 2014) and up to 70% of familial ALS patient motor neurons, bearing SOD1, FUS or optineurin mutations (Fujita et al., 2008; Ito et al., 2011).