Furthermore, we have also demonstrated that misfolded WT SOD1 also impairs ER-Golgi trafficking similar to mutant SOD1, resulting in ER stress and Golgi fragmentation (Sundaramoorthy et al., 2015), although it remains controversial whether misfolded WT SOD1 is present in sporadic ALS tissues (Liu et al., 2009; Forsberg et al., 2010; Grad et al., 2014). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.