Moreover, CD24-mediated tumor propagation has also been associated with an increase of local invasiveness: CD24 mediated invasion of cancer cells has been hypothesized as a result of increased contractile forces as indicated by the findings of A125 human lung cancer cells with different CD24 expression levels using CD24-high and CD24-low transfectants in three-dimensional extracellular matrix (ECM) invasion assays [19]. This evidence concerns the gene CD24 and lung cancer.