To pinpoint the signalling pathways, responsible for imiquimod‐induced expression of Noxa, both melanoma cell lines BLM and MV3 were treated with imiquimod, when pre‐treated with the inhibitors of JNK (SP600125), p38 (SB203580) and IRE1α (irestatin) 1 hr before treatment with imiquimod. Here, PMAIP1 is linked to melanoma.