Figure 2D and E demonstrate the induction of Noxa, degradation of Mcl‐1, increased cytochrome c release and cleavage of caspase‐9, caspase‐3 and PARP, during the treatment with imiquimod, suggesting the contribution of mitochondrial dysregulation‐dependent pathways in the modulation of imiquimod‐induced apoptosis of melanoma cells. This evidence concerns the gene CYCS and melanoma.