PMAIP1 and melanoma: Figure 2D and E demonstrate the induction of Noxa, degradation of Mcl‐1, increased cytochrome c release and cleavage of caspase‐9, caspase‐3 and PARP, during the treatment with imiquimod, suggesting the contribution of mitochondrial dysregulation‐dependent pathways in the modulation of imiquimod‐induced apoptosis of melanoma cells.