As expected, EMSA demonstrated the enhanced DNA‐binding activity of the different transcription factors AP‐1 (Fig. 3C and D), ATF‐2 (Fig. 3E and F), p53 (Fig. 3G and H) and ELK‐1 (Fig. 3I and J) in both melanoma cell lines BLM and MV3 upon imiquimod treatment. Here, TP53 is linked to melanoma.