Figure 2D and E demonstrate the induction of Noxa, degradation of Mcl‐1, increased cytochrome c release and cleavage of caspase‐9, caspase‐3 and PARP, during the treatment with imiquimod, suggesting the contribution of mitochondrial dysregulation‐dependent pathways in the modulation of imiquimod‐induced apoptosis of melanoma cells. The gene discussed is MCL1; the disease is melanoma.