Based on the observation that levels of IL-27 and IL-27 receptor were elevated in VMC, as well as the negative association between IL-27 levels and the severity of VMC, we examined the efficacy of IL-27 in the VMC mouse model, with the use of anti- IL-27 antibody and recombinant mouse IL-27, respectively. The gene discussed is IL27; the disease is liver mesenchymal hamartoma.