By contrast, a one-hour ZOL treatment in combination with US increased statistically significantly the intracellular accumulation of IPP in tumor cells, compared with either treatment alone (1,967 ± 882 and 109 ± 61 pmol/mg protein in US+ZOL- and ZOL-treated tumor cells, respectively; P < 0.01). This evidence concerns the gene IPP and neoplasm.