The GBG 26/BIG 3–05 phase III study, which included patients with HER2+ locally advanced or metastatic BC who had progressed during treatment with trastuzumab, reported no improvement in OS, but a statistically significant improvement of PFS in patients that received capecitabine with continuation of trastuzumab compared with those that received capecitabine alone (24.9 vs. 20.6 months, p = 0.73; 8.2 vs. 5.6 months, p = 0.0338, respectively) (von Minckwitz et al. [29], von Minckwitz et al. [30]). The gene discussed is ERBB2; the disease is breast cancer.