ERBB2 and breast cancer: Since the addition of trastuzumab to anthracyclines resulted in high incidence of cardiac toxicity in the pivotal trial conducted by Slamon and colleagues, Baselga and colleagues conducted a trial of first-line nonpegylated liposomal doxorubicin plus trastuzumab and paclitaxel versus trastuzumab and paclitaxel alone in patients with HER2+ metastatic BC (Slamon et al. [1]; Baselga et al. [14]).