The results showed that, compared with control cells, not only the gene expression of DR4 and DR5 but also protein expression of these receptors were significant higher in HBX-Huh-7 cells than in control cells (Fig. 2a-b), suggesting that HBX could upregulate the expressions of DR4 and DR5 in hepatoma cells. Here, TNFRSF10A is linked to hepatocellular carcinoma.