HMGCR and diabetes mellitus: With regard to the mechanism of this effect, the most recent meta-analysis of the effect of statins on incident diabetes was accompanied by a Mendelian randomisation analysis showing that in large association studies participants with LDL-c-lowering single-nucleotide polymorphisms in the 3-hydroxy-methylglutaryl-CoA reductase gene (with an allele effect on LDL-c of 0.06 mmol/l on average) had slightly higher rates of type 2 diabetes (OR per allele 1.02 [95% CI 1.00, 1.05]).