GLP1R and diabetes mellitus: Approximately 50% of Americans with diabetes continue to have HbA1c values above 7% (53.00 mmol/mol) [3] and, while a systematic review showed there to be variability with regard to attainment of an HbA1c goal of <7% (53.00 mmol/mol) among the different classes of glucose-lowering agents, glucagon-like peptide-1 (GLP-1) analogues achieved the highest percentage [4].